Locust Grove is a city in Henry County, Georgia, United States. The population was 5,402 at the 2010 census, up from 2,322 in 2000. Some unincorporated communities such as Luella and many rural areas surround Locust Grove, and those communities have Locust Grove postal addresses.
Locust Grove is located in southern Henry County at 33°20′44″N 84°6′18″W / 33.34556°N 84.10500°W / 33.34556; -84.10500 (33.345499, -84.104991). U.S. Route 23 passes through the center of town, leading north 7 miles (11 km) to McDonough, the county seat, and southeast 10 miles (16 km) to Jackson. Interstate 75 passes through the western portion of Locust Grove, with access from Exit 212 (Bill Gardner Parkway). I-75 leads northwest 36 miles (58 km) to downtown Atlanta and southeast 49 miles (79 km) to Macon.